The stainless steel in-line filter has virtually no hold-up volume and can be used in various applications without significant band broadening or loss of efficiency. The 0.25 mm bore versions are intended for analytical use between autosampler/injection valve and column. The 0.75 mm bore versions are suitable for higher flow rates in semi-prep systems or for solvent supply from pump to autosampler. With minimal dead volume and available frit porosities of 0.5, 2 or 5 μm, these in-line filters are the ideal column protectors